![]() ![]() The reported sensitivity and specificity of CT scan findings are in the range of 90-95%. Minor criteria include gallbladder wall thickening greater than 3mm, pericholecystic fluid, and gallbladder dilatation. The 2 major diagnostic criteria are cholelithiasis and sonographic Murphy’s sign. Sonography is a sensitive and specific modality for diagnosis of acute cholecystitis adjusted sensitivity and specificity for diagnosis of acute cholecystitis are 88% and 80%, respectively. Patients with acute cholecystitis are much more likely to manifest abnormal laboratory values, while in chronic cholecystitis the laboratory values are frequently normal. ![]() The degree of elevation of these laboratory values may depend on the degree of inflammation of the gallbladder. CRP (C-reactive protein) is often elevated. Laboratory values may be notable for an elevated alkaline phosphatase, possibly an elevated bilirubin (although this may indicate choledocholithiasis), and possibly an elevation of the WBC count.
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